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US 8,002,821 B2Granted
Bioerodible metallic ENDOPROSTHESES
AssigneeBoston Scientific Scimed, Inc.
InventorJonathan S. Stinson
Life of this patent
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Abstract
Endoprostheses such as stents are disclosed that are, or that include portions that are, bioerodible.
Claims8
An implantable endoprosthesis comprising:
- a bioerodible body comprising a first bioerodible metallic material, the bioerodible body having a thickness of between about 0.5 mm and about 5.0 mm;
- and
- a plurality of discrete, spaced apart bioerodible deposits comprising a second bioerodible metallic material different from the first bioerodible metallic material, said deposits of the second bioerodible metallic material overlying the first bioerodible metallic material at a plurality of regions, each deposit having a thickness of between about 0.01 μm to about 5 μm;
- each region having a surface area of not more than about 25 μm2, wherein the second bioerodible metallic material forms a continuous interface with the first bioerodible metallic material over the entirety of each region;
- wherein a longitudinal spacing between immediately adjacent deposits is between about 1.0 μm and about 35 μm;
- wherein a transverse spacing between immediately adjacent deposits is between about 1.0 μm and about 35 μm, measured along an outer surface of the bioerodible body from which the deposits extend;
- wherein, when implanted within a body lumen, the bioerodible body and each deposit together define a galvanic couple that enhances a rate of erosion of the discrete, spaced apart bioerodible deposits, and wherein a standard cell potential for the galvanic couple is at least +1.0 V;
- wherein erosion of the discrete, spaced apart bioerodible deposits creates crevices in the bioerodible body proximate the discrete, spaced apart bioerodible deposits, and wherein the crevices in the bioerodible body have an enhanced rate of erosion resulting in the body disintegrating into fragments having a maximum dimension of not more than 15 μm.
5 more elements
Dependencies are inferred from the claim text.