Method and composition for removing uremic toxins in dialysis processes
AssigneeBaxter International Inc.
InventorsSujatha Karoor, Brian Donovan, Ton That Hai, Mari Katada, Luis Lu, Leo Martis, Stavroula Morti, Salim Mujais, Paul J. Sanders, Paul J. Soltys, Rahul Tandon
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Abstract
Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.
Claims17
A device for removing uremic toxins in a dialysis procedure, the device comprising:
- a body having an inlet and an outlet and defining an interior, the interior including a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon;
- and
- the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the urease layer.
A device for removing uremic toxins in a dialysis procedure, the device comprising:
- a body having an inlet and an outlet and defining an interior, the interior including:
- a modified urease layer comprising a modified urease selected from the group consisting of cross-linked enzyme crystals of urease, a blend of urease and zirconium oxide, alumina-stabilized urease and combinations thereof,
- a layer comprising zirconium oxide,
- a layer comprising zirconium phosphate, and
- a layer comprising carbon;
- and
- the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the modified urease layer.
A device for removing uremic toxins in a dialysis procedure, the device comprising:
- a body having an inlet and an outlet and defining an interior, the interior including a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon;
- and
- the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the urease layer, wherein the fluid flows through the urease layer before entering the layer of zirconium oxide.
A device for removing uremic toxins in a dialysis procedure, the device comprising:
- a body having an inlet and an outlet and defining an interior, the interior including a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein the zirconium oxide is in a bicarbonate form;
- and
- the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the urease layer.
A device for removing uremic toxins in a dialysis procedure, the device comprising:
- a body having an inlet and an outlet and defining an interior, the interior including:
- a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, and
- a second separate layer comprising zirconium phosphate, the urease layer positioned between the layer comprising zirconium phosphate and the second separate layer comprising zirconium phosphate;
- and
- the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the urease layer.
A device for removing uremic toxins in a dialysis procedure, the device comprising:
- a body having an inlet and an outlet and defining an interior, the interior including:
- a modified urease layer comprising a modified urease selected from the group consisting of cross-linked enzyme crystals of urease, a blend of urease and zirconium oxide, alumina-stabilized urease and combinations thereof,
- a layer comprising zirconium oxide,
- a layer comprising zirconium phosphate, and
- a layer comprising carbon, and
- a second separate layer comprising zirconium phosphate, the modified urease layer positioned between the layer comprising zirconium phosphate and the second separate layer comprising zirconium phosphate;
- and
- the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the modified urease layer.
Dependencies are inferred from the claim text.