Shape parameter for hematology instruments
AssigneeBeckman Coulter, Inc.
InventorsJiuliu Lu, Phaisit Chewputtanagul
Life of this patent
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Abstract
Systems, methods, and computer program products are provided for describing characteristics of a data sample. This description is used to represent the shape of a histogram of the data sample.
Claims32
A method for describing characteristics of a data sample, the method comprising:
- generating a multi-dimensional histogram from data representative of a plurality of physical measurement parameters on a detected object;
- determining a central portion of the histogram;
- and
- computing a shape parameter for the histogram along a slicing line originating at the central portion;
- wherein generating a multi-dimensional histogram, determining the central portion of the histogram, computing the shape parameter for the histogram, or any combination thereof is implemented using a programmed computer system.
A system for describing characteristics of a data sample, comprising:
- generating module to generate a histogram from data representative of physical measurements on a detected object;
- determining module to determine a central portion of the histogram;
- and
- computing module to compute a shape parameter for the histogram along a slicing line originating at the central portion;
- wherein generating module, determining module, computing module, or any combination thereof is implemented using a programmed computer system.
A computer program product comprising a computer-usable medium having computer program logic recorded thereon that, when executed by a processor, causes the processor to describe characteristics of a data sample, the computer program logic comprising:
- generating module configured to enable the processor to generate a histogram from data representative of physical measurements on a detected object;
- determining module configured to enable the processor to determine a central portion of the histogram;
- and
- computing module configured to enable the processor to compute a shape parameter for the histogram along a slicing line originating at the central portion.
A computer-readable storage medium having computer program code recorded thereon that, when executed by a processor, causes the processor to perform a method for describing characteristics of a data sample, the method comprising:
- generating a histogram from data representative of physical measurements on a detected object;
- determining a central portion of the histogram;
- and
- computing a shape parameter for the histogram along a slicing line originating at the central portion.
A method for describing characteristics of a population of blood cells, comprising:
- acquiring a blood cell from the population of blood cells in an instrument aperture;
- obtaining data representative of two physical measurements for the blood cell;
- determining a population type of the population based on the data;
- generating a two-dimensional histogram from data, wherein the data is aggregated with additional data corresponding to the population to generate the histogram;
- determining a central portion of the histogram;
- and
- computing a shape parameter for the histogram along a slicing line originating at the central portion;
- wherein acquiring the blood sample, obtaining data, determining the population type, generating a two-dimensional histogram, determining the central portion of the histogram, computing the shape parameter for the histogram, or any combination thereof is implemented using a programmed computer system.
A method for detecting irregularities in a biological sample, comprising:
- generating a histogram from data representative of physical measurements on the biological sample;
- determining a central portion of the histogram;
- interpolating frequency values for the histogram along a slicing line originating at the central portion;
- calculating the shape parameter using the interpolated frequency values;
- creating a plot of the shape parameter against an angle of the slicing line;
- and
- comparing the plot to an expected plot;
- wherein generating the histogram, determining the central point of the histogram, interpolating frequency values for the histogram, calculating the shape parameter, creating a plot of the shape parameter, comparing the plot to the expected plot, or any combination thereof is implemented using a programmed computer system.
A particle analyzer system comprising:
- a flow chamber;
- a detector configured to generate electronic signals responsive to particles passing through the flow chamber;
- a receiver configured to receive the electrical signals and to convert the electrical signals to captured data;
- and
- a data processor, comprising:
- a generating module to generate a histogram from the captured data;
- a removing module to remove a portion of the histogram having a characteristic below a first threshold value;
- a smoothing module to smooth a remaining portion of the histogram through removing an additional portion of the remaining portion having a characteristic below a second threshold value;
- a determining module to determine a central portion of the histogram;
- and
- a computing module to compute a shape parameter for the histogram along a slicing line originating at the central portion;
- and
- a display configured to display a plot of the shape parameter against an angle of the slicing line.
Dependencies are inferred from the claim text.