Encapsulated vaccines for the oral vaccination and boostering of fish and other animals
AssigneeAdvanced Bionutrition Corporation
InventorMoti Harel
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Abstract
The invention relates to a composition comprising a pharmaceutically active agent and a bioadhesive delivery system that provides for the oral delivery of a vaccine to animals, particularly aquatic animals.
Claims11
A composition for oral administration to an animal for intestinal delivery of a pharmaceutically active agent, said composition comprising:
- a) at least one bioadhesive polymer selected from the group consisting of chitosan, hyaluronic acid, cationic guar, and combinations thereof;
- wherein the bioadhesive polymer is present at a concentration of between 1% and 10%;
- b) at least one oligosaccharide selected from the group consisting of inulin, fructooligosaccharide and dextrin, wherein the oligosaccharide is present at a concentration of between 1% and 50%;
- c) at least one mediating compound having both hydrophilic and lipophilic properties, wherein the mediating compound comprises an emulsifier/sugar complex containing 0.5 to 12.5% w/w emulsifier and 5-30% w/w sugar, and d) a pharmaceutically active agent.
A composition for stabilizing and delivery of a pharmaceutically active agent to the gut of a fish, the composition comprising chitosan and inulin in combination with an emulsifier/sugar complex wherein the emulsifier/sugar complex comprises 0.5 to 12.5% w/w emulsifier and 5-30% w/w sugar, wherein the emulsifier/sugar complex comprises lecithin and is in an amount sufficient to mediate the interaction between inulin and the hydrophobic amine residues of chitosan, and wherein the pharmaceutically active agent is a Salmon Rickettsial Septicaemia (SRS) vaccine.
Dependencies are inferred from the claim text.