Antitoxin and vaccine platform based on nodavirus VLPs
AssigneesThe Salk Institute for Biological Studies, The Scripps Research Institute
InventorsJohn Young, Anette Schneemann, Marianne Manchester, Kelly Dryden, John M. Marlett, Darly Joseph Manayani, Godfrey Jonah Anderson Rainey, Vijay Reddy, Marc E. Siladi, Heather M. Scobie, Diane Thomas, Mark Yeager
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Abstract
Antitoxin and vaccine compositions based on nodavirus VLPs are provided. Anthrax antitoxin and vaccine compositions are provided. Methods of treating toxins with VLP-based antitoxins are provided. Methods of raising an immune response with immunogen decorated VLPs are provided.
Claims8
An immunogenic composition comprising a nodavirus-derived virus like particle (VLP) that comprises a heterologous immunogen binding domain, which binding domain is bound to a first heterologous immunogen, wherein the binding domain comprises a VWA domain of capillary morphogenesis protein 2 (ANTRX2) and the heterologous immunogen is derived from an anthrax toxin.
Dependencies are inferred from the claim text.