Method of fabricating a tissue engineering scaffold
AssigneeWisconsin Alumni Research Foundation
InventorsLih-Sheng Turng, Adam J. Kramschuster
Life of this patent
Estimating the term…
Abstract
A method of fabricating a highly porous structure is provided. The method includes the step of compounding a biodegradable polymer, a water-soluble polymer and a porogen to form a composite blend. A foaming agent is dissolved into the composite blend and the composite blend is injected into a mold so as to form the structure. Thereafter, the structure is removed from the mold and leached in a fluid.
Claims20
A method of fabricating a highly porous structure, comprising the steps of:
- blending a biodegradable polymer, a water-soluble polymer and a porogen to form a composite blend;
- introducing a gas in a supercritical state into composite blend;
- mixing the gas into the composite blend to a form a single-phase solution prior to injecting the composite blend into the mold;
- injecting the single-phase solution into a mold;
- processing the single-phase solution in the mold to generate the structure;
- and
- leaching the structure in a fluid for a time period such that the water-soluble polymer is extracted from the structure.
A method of fabricating a highly porous structure, comprising the steps of:
- compounding a biodegradable polymer, a water-soluble polymer and a porogen to form a composite blend;
- dissolving a foaming agent into the composite blend;
- mixing the foaming agent and composite blend to form a single-phase solution;
- injecting the single-phase solution into a mold to form the structure;
- and
- leaching the structure in a fluid such that the water-soluble polymer is extracted from the structure.
A method of fabricating a highly porous structure, comprising the steps of:
- introducing a foaming agent into a compound including a biodegradable polymer, a water-soluble polymer and a porogen;
- mixing the foaming agent and the compound within a barrel of an injection molding machine;
- injecting the mixture of the foaming agent and the compound into a mold under pressure;
- processing the compound in the mold to form the structure;
- and
- leaching the structure in a fluid such that the water-soluble polymer is extracted from the structure.
Dependencies are inferred from the claim text.