Back to results
US 7,994,362 B2Granted
Histone deacetylases, and uses related thereto
AssigneePresident and Fellows of Harvard College
InventorsStuart L. Schreiber, Jack Taunton, Christian A. Hassig, Timothy F. Jamison
Life of this patent
Estimating the term…
Abstract
The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
Claims4
A composition comprising a compound represented by the formula A-B-C, wherein:
- A is
- wherein R1 represents an alkyl group substituted by one or more moieties selected from the group consisting of halogen, hydroxyl, carboxylate, alkoxycarbonyl, aryloxycarbonyl, alkylcarbonyl, arylcarbonyl, aldehyde, thiocarbonyl, alkoxyl, unsubstituted amino, monosubstituted amino, disubstituted amino, amido, amidine, imine, nitro, azido, sulfhydryl, alkylthio, cyano, trifluoromethyl, sulfonato, sulfamoyl, sulfonamido, heterocyclyl, aralkyl, aromatic, and heteroaromatic moieties;
- B is a substituted or unsubstituted C2-C8 alkenylidene;
- and
- C is
- wherein Y is O
- or a pharmaceutically acceptable salt thereof,
- wherein the compound inhibits a histone deacetylase.
5 more elements
Dependencies are inferred from the claim text.