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US 7,993,867 B2Granted
Diagnosis, prevention and treatment of crohn's disease using the OmpC antigen
AssigneesCedars-Sinai Medical Center, The Regents of the University of California
InventorsStephan R. Targan, Jonathan Braun, Christopher L. Sutton
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Abstract
The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
Claims12
An assay to aid in the detection of Crohn's disease comprising:
- (a) contacting a sample with an outer membrane protein antigen (OmpC antigen) or reactive fragment thereof, under conditions suitable to transform said OmpC antigen into a complex comprising OmpC antigen or reactive fragment thereof, and an IgA anti-OmpC antibody present in the sample;
- (b) contacting said complex with an enzyme labeled indicator antibody to bind said complex with said enzyme labeled indicator antibody and thus transform said complex into a labeled complex;
- (c) contacting said labeled complex with a substrate for said enzyme;
- and
- (d) detecting the IgA anti-OmpC antibodies in said labeled complex, the presence of said IgA anti-OmpC antibodies providing an aid in the detection of Crohn's Disease.
2 more elements
Dependencies are inferred from the claim text.