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US 7,993,865 B2Granted
Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen
AssigneesCedars-Sinai Medical Center, The Regents of the University of California
InventorsStephan R. Targan, Jonathan Braun, Christopher L. Sutton
Life of this patent
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Abstract
The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
Claims11
An assay system to aid in the detection of Crohn's disease, said assay system comprising:
- (a) a plate comprising an OmpC antigen, or reactive fragment thereof, wherein said OmpC antigen comprises the amino acid sequence of SEQ ID NO:1 or 90% identity thereof;
- (b) an indicator secondary antibody specific for an OmpC autoantibody;
- and
- (c) instructions that specifically detect for Crohn's Disease by detecting for the presence of a complex of said OmpC antigen in (a), said OmpC autoantibody, and said indicator secondary antibody that specifically binds said OmpC autoantibody in (b), the presence of the formed complex having the OmpC autoantibody being indicative of Crohn's Disease.
1 more element
An assay kit for improving the diagnosis of Crohn's disease comprising:
- (a) a plate well containing an OmpC antigen, or reactive fragment thereof;
- (b) an enzyme-labeled anti IgA antibody;
- and
- (c) instructions that specifically detect for Crohn's Disease by detecting for the presence of a complex of said OmpC antigen in (a), said OmpC autoantibody, and said indicator secondary antibody that specifically binds said OmpC autoantibody in (b), the presence of the formed complex having the OmpC autoantibody being indicative of Crohn's Disease.
1 more element
Dependencies are inferred from the claim text.