US 7,989,661 B2 · Human ADAM-10 inhibitors

Abstract

The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.

Claims10

Dependent claims

A method of making a bis-aryl ether sulfonyl halide according to formula VII:

wherein X is a halide;
and W1 and W2 are each independently an optionally substituted aryl, the method comprising:
(a) combining a metal-aryloxide salt of a corresponding hydroxide-substituted aryl compound with a fluoro-substituted nitro aryl compound to make a bis-aryl ether nitro-aromatic compound;
(b) reducing a nitro group of the bis-aryl ether nitro-aromatic compound to produce a corresponding aniline derivative;
and (c) converting the corresponding aniline derivative to the bis-aryl ether sulfonyl halide.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

12/605,118Filed 23 Oct 2009 · division

Priority

12 Jun 2002

Published

US 2010/0105953 A129 Apr 2010

Granted

2 Aug 2011

Term ends

Not estimatedThe source records don’t support an estimate.

Classification23 codes

C07D 241/04
Not condensed with other rings: having no double bonds between ring members or between ring members and non-ring members
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
A61P 9/00
Drugs for disorders of the cardiovascular system

Family

Application60/388,326Us provisional application · filed 12 Jun 2002

PCT/US03/18262Parent of this division · filed 11 Jun 2003

US 2010/0105953 A1Pre-grant publication · published 29 Apr 2010

Application10/518,110Parent of this division

US 7,629,341 B2Parent of this division

US 2006/0199820 A1Published application

US 7,989,661 B2This patent

From the US filing history. Foreign family members aren’t listed.

Human ADAM-10 inhibitors

Life of this patent

Human ADAM-10 inhibitors

Life of this patent

Abstract

Claims10