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US 7,988,973 B2Granted
Activin-ActRII antagonists and uses for increasing red blood cell levels
AssigneeAcceleron Pharma Inc.
InventorMatthew L. Sherman
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Abstract
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Claims37
A method for treating an anemia, the method comprising administering, to a subject in need thereof, an effective amount of a polypeptide selected from the group consisting of:
- a) a polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO:2;
- b) a polypeptide comprising the amino acid sequence of SEQ ID NO:2;
- c) a polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO:3;
- and
- d) a polypeptide comprising the amino acid sequence of SEQ ID NO:3,
- and wherein the polypeptide binds to activin.
3 more elements
Dependencies are inferred from the claim text.