Immunoreactive peptides from Epstein-Barr virus
AssigneeOrtho-Clinical Diagnostics, Inc.
InventorsRichard S. Smith, Gary R. Pearson, D. Elliot Parks, Susan Pothen Varghese
Life of this patent
Estimating the term…
Abstract
The Epstein-Barr virus (EBV) specific polypeptides ETFTETWNRFITHTE (SEQ. ID NO: 1), GMLEASEGLDGWIHQ (SEQ. ID NO:2), HQQGGWSTLIEDNIP (SEQ. ID NO:3), and KQKHPKKVKQAFNPL (SEQ. ID NO:4) are among those disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment of EBV-associated disease.
Claims5
A monoclonal antibody to a polypeptide consisting of an amino acid sequence having the formula:
- (φ)n
- wherein n is 1 to about 1000 and φ is 19 amino acids or less and has the formula:
- (α ETFTETWNRFITHTE β)n
- (SEQ. ID NO:
- 7)
- (α GMLEASEGLDGWIHQ β)n
- (SEQ. ID NO:
- 8)
- (α HQQGGWSTLIEDNIP β)n
- (SEQ. ID NO:
- 9)
- (α KQKHPKKVKQAFNPL β)n
- (SEQ. ID NO:
- 10)
- wherein α and β are independently from 0 to about 2 naturally occurring amino acids wherein the polypeptide is capable of binding antibody in a specimen from an individual with Epstein-Barr virus (EBV)-associated disease.
A kit useful for detection of an amino acid sequence comprising a polypeptide consisting of an amino acid sequence with the formula:
- (φ)n
- wherein n is 1 to about 1000 and φ is 19 amino acids or less and has the formula:
- (α ETFTETWNRFITHTE β)n
- (SEQ. ID NO:
- 7)
- (α GMLEASEGLDGWIHQ β)n
- (SEQ. ID NO:
- 8)
- (α HQQGGWSTLIEDNIP β)n
- (SEQ. ID NO:
- 9)
- (α KQKHPKKVKQAFNPL β)n
- (SEQ. ID NO:
- 10)
- wherein α and β are independently from 0 to about 2 naturally occurring amino acids, wherein the polypeptide is capable of binding antibody in a specimen from an individual with Epstein-Barr virus (EBV)-associated disease in a specimen suspected of containing such sequence, the kit comprising carrier means being compartmentalized to receive in close confinement therein one or more containers comprising a container containing a monoclonal antibody to said polypeptide.
Dependencies are inferred from the claim text.