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US 7,985,950 B2Granted
Parallel mass analysis
AssigneeThermo Fisher Scientific (Bremen) GmbH
InventorsAlexander A. Makarov, Stevan Horning
Life of this patent
Estimating the term…
Abstract
A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.
Claims47
A method of mass spectrometry comprising:
- generating ions in an ion source;
- storing ions from the ion source in a first ion storage device, having at least an ion transport aperture, during a first ion storage time;
- ejecting ions from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period;
- storing ions from the ion source in a second ion storage device, having at least an ion transport aperture, during a second ion storage time;
- and
- ejecting ions from the second ion storage device to a second mass analysis device during a second ejection time period, for analysis during a second analysis time period;
- wherein the ion storage devices are connected in series such that the ion transport aperture of the first ion storage device is in communication with the ion transport aperture of the second ion storage device so as to allow transfer of ions between the first and second ion storage devices, and further wherein the first analysis time period and the second ejection time period at least partly overlap.
4 more elements
A method of mass spectrometry comprising:
- generating ions in an ion source;
- storing ions from the ion source in a first storage volume of an ion storage device, during a first ion storage time;
- ejecting ions from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period;
- storing ions from the ion source in a second storage volume of the ion storage device during a second ion storage time, the second storage volume at least partly overlapping with said first storage volume;
- and
- ejecting ions from the ion storage device to a second mass analysis device during a second ejection time period, for analysis during a second analysis time period;
- wherein the first analysis time period and the second ejection time period at least partly overlap.
4 more elements
A method of mass spectrometry comprising:
- generating ions in an ion source;
- and
- performing the following steps for each of a plurality of mass analysis devices:
- storing ions from the ion source in an ion storage device during a respective storage time period;
- and
- ejecting ions from the ion storage device to the respective mass analysis device, the mass analysis device being arranged to analyse the respective ejected ions during a respective analysis time period;
- wherein the number of mass analysis devices comprising the plurality of mass analysis devices is substantially equal to or greater than the ratio of the analysis time period to a representative storage time period, the representative storage time period being based on at least one of the respective storage time periods for each of the plurality of mass analysis devices.
4 more elements
A mass spectrometry system comprising:
- an ion source;
- a first mass analysis device, arranged to analyse ions during a first analysis time period;
- a second mass analysis device, arranged to analyse ions during a second analysis time period;
- a first ion storage device, arranged to store ions and having at least an ion transport aperture;
- a second ion storage device, arranged to store ions and having at least an ion transport aperture, the second ion storage device being connected in series with the first ion storage device, such that the ion transport aperture of the first ion storage device is in communication with the ion transport aperture of the second ion storage device so as to allow transfer of ions between the first and second ion storage devices;
- and
- a system controller, arranged to control the first ion storage device to store ions in the first ion storage device in a first storage time and to eject said ions to the first mass analysis device during a first ejection time period, the system controller being further arranged to control the second ion storage device to store ions from the ion source in the second ion storage device in a second storage time and to eject said ions to the second mass analysis device during a second ejection time period, which at least partly overlaps with the first analysis time period.
4 more elements
A mass spectrometry system comprising:
- an ion source;
- a first mass analysis device, arranged to analyse ions during a first analysis time period;
- a second mass analysis device, arranged to analyse ions during a second analysis time period;
- an ion storage device, arranged to store ions in a first storage volume and further arranged to store ions in a second storage volume, the second storage volume at least partly overlapping with said first storage volume;
- and
- a system controller, arranged to control the ion storage device to store ions from the ion source in the first storage volume in a first storage time and to eject said ions to the first mass analysis device during a first ejection time period, the system controller being further arranged to control the ion storage device to store ions from the ion source in the second storage volume in a second storage time and to eject said ions to the second mass analysis device during a second ejection time period, which at least partly overlaps with the first analysis time period.
3 more elements
A mass spectrometry system comprising:
- an ion source;
- an ion storage device, arranged to store ions;
- a plurality of mass analysis devices;
- and
- a system controller, arranged for each mass analysis device from the plurality of mass analysis devices, to control the ion storage device to store ions from the ion source in a respective storage time period and to eject ions from the ion storage device to the respective mass analysis device in a respective ejection time period, and to control each of the plurality of mass analysis devices to analyse the respective ejected ions during a respective analysis time period;
- wherein the number of mass analysis devices comprising the plurality of mass analysis devices is substantially equal to or greater than the ratio of the analysis time period to a representative storage time period, the representative storage time period being based on at least one of the respective storage time periods for each of the plurality of mass analysis devices.
3 more elements
Dependencies are inferred from the claim text.