Nanoscale array biomolecular bond enhancer device
AssigneeSRI International
InventorPatrick Denis Lincoln
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Abstract
The invention teaches the use of an addressable nanoscale device to create a programmable substrate useful in selectively attracting proteins, nucleating protein crystals and growing protein crystals of a size amenable to diffraction analysis. Further taught is the use of nanoscale assemblies to create charge patterns, where such charge patterns are useful in purifying, nucleating or crystallizing protein molecules. Charge extension moieties, including water, are taught. The invention provides rapid and efficient identification, purification and detection of proteins and protein-related complexes.
Claims16
A device for providing a purification of biomolecules, said device comprising:
- a nanoscale substrate supporting an addressable nanoscale array, the addressable nanoscale array being programmable with charge patterns for selective molecule attraction;
- and
- a means for exposing biomolecules, where said biomolecules are in a form amenable to a directable flow, to the nanoscale substrate in a manner such that the biomolecules are collected, thereby improving the purification of said biomolecules.
Dependencies are inferred from the claim text.