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US 7,982,060 B2Granted
Intermediates for the preparation of analogs of Halichondrin B
AssigneeEisai R&D Management Co., Ltd.
InventorsBrian Austad, Charles E. Chase, Francis G. Fang
Life of this patent
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Abstract
The present invention provides macrocyclic compounds, synthesis of the same and intermediates thereto. Such compounds, and compositions thereof, are useful for treating or preventing proliferative disorders Formula (F-4).
Claims18
A compound of formula F-4:
- wherein:
- each of PG1, PG2, and PG3 is independently hydrogen or a suitable hydroxyl protecting group;
- R1 is R or —OR;
- each R is independently hydrogen, C1-4 haloaliphatic, benzyl, or C1-4 aliphatic;
- and
- LG1 is a suitable leaving group.
3 more elements
Dependencies are inferred from the claim text.