Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods
AssigneeThe Trustees of Columbia University in the City of New York
InventorsJingyue Ju, Qinglin Meng, Dae H. Kim, Lanrong Bi, Xiaopeng Bai, Nicholas J. Turro
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Abstract
This invention provides a process for making 3′-O-allyl-dGTP-PC-Biodopy-FL-510, 3′-O-allyl-dATP-PC-ROX, 3′-O-allyl-dCTP-PC-Bodipy-650 and 3′-O-allyl-dUTP-PC-R6G, and related methods.
Claims4
A method for making 3′O-allyl-dGTP-PC-Bodipy-FL-510 comprising performing the steps set forth in FIG. 7.
A method for making 3′-O-allyl-dATP-PC-ROX comprising performing the steps set forth in FIG. 8.
A method for making 3′-(D-allyl-dCTP-PC-Bodipy-650 comprising performing the steps set forth in FIG. 9.
A method for making 3′-O-allyl-dUTP-PC-R6G comprising performing the steps set forth in FIG. 10.
Dependencies are inferred from the claim text.