Triazole macrocycle systems

A peptidomimetic macrocycle of Formula (I):

• wherein:
• each A, C, D, and E is independently a natural or non-natural amino acid;
• B is a natural or non-natural amino acid, amino acid analog,
• [—NH-L3-CO—], [—NH-L3-SO2—], or [—NH-L3-];
• R1 and R2 are independently —H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl, or heterocycloalkyl, each non-H group being optionally substituted with halo-;
• R3 is hydrogen, alkyl, alkenyl, alkynyl, arylalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, cycloaryl, or heterocycloaryl, each non-H group being optionally substituted with R5;
• L is a macrocycle-forming linker of the formula
• L1, L2 and L3 are independently alkylene, alkenylene, alkynylene, heteroalkylene, cycloalkylene, heterocycloalkylene, cycloarylene, heterocycloarylene, or [—R4—K—R4—]n, each being optionally substituted with R5;
• each R4 is alkylene, alkenylene, alkynylene, heteroalkylene, cycloalkylene, heterocycloalkylene, arylene, or heteroarylene;
• each K is O, S, SO, SO2, CO, C(═O)—O—, or CONR3;
• each R5 is independently halogen, alkyl, —OR6, —N(R6)2, —SR6, —SOR6, —SO2R6, —CO2R6, a fluorescent moiety, a radioisotope or a therapeutic agent;
• each R6 is independently —H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkylalkyl, heterocycloalkyl, a fluorescent moiety, a radioisotope or a therapeutic agent;
• R7 is —H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heterocycloalkyl, cycloaryl, or heterocycloaryl, each non-H group being optionally substituted with R5, or part of a cyclic structure with a D residue;
• R8 is —H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heterocycloalkyl, cycloaryl, or heterocycloaryl, each non-H group being optionally substituted with R5, or part of a cyclic structure with an E residue;
• v is an integer from 1-1000;
• w is an integer from 1-1000;
• x is an integer from 0-10;
• y is an integer from 0-10;
• z is an integer from 0-10;
• and
• n is an integer from 1-5;
• wherein the peptidomimetic macrocycle comprises an α-helix or beta sheet.