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US 7,981,878 B2Granted
Tumor treatment with gliotoxin derivatives
AssigneeMedizinische Universität Wien
InventorsRainer Hubmann, Wolfgang Sieghart
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Abstract
The present invention describes the use of Notch2 inhibitors for producing a medicament for the treatment of tumours, which tumours are characterized by ligand-independent Notch2 fragments.
Claims17
A method for the treatment of a cancer having ligand-independent Notch2 fragments comprising:
- diagnosing a cancer as a cancer having ligand-independent Notch2 fragments based on the detection of ligand-independent Notch2 fragments in the cancer;
- obtaining a gliotoxin or gliotoxin derivative;
- and
- administering an effective amount of the gliotoxin or gliotoxin derivative to a subject having the cancer having ligand-independent Notch2 fragments;
- wherein the cancer having ligand-independent Notch2 fragments is treated.
2 more elements
Dependencies are inferred from the claim text.