Treatment of Parkinson's disease with PDGF
AssigneeNeuroNova AB
InventorsKioumars Delfani, Ann Marie Janson, H. Georg Kuhn, Karlheinz Plate, Anne Schanzer, Frank-Peter Wachs, Ming Zhao
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Abstract
The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells. These methods are useful for reducing at least one symptom of the disorder.
Claims14
A method of treating a patient with Parkinson's disease or Parkinsonian disorders comprising administering PDGF-BB in vivo directly to the central nervous system of said patient, wherein the PDGF-BB is administered in an amount of between 0.5 ng/kg/day to 500 ng/kg/day.
A method for inducing the in situ proliferation or differentiation of neural stem cells or neural progenitor cells located in a neural tissue of a human, the method comprising administering an amount of PDGF-BB of between 0.5 ng/kg/day to 500 ng/kg/day, to the neural tissue to induce the proliferation or differentiation of the neural stem cells or neural progenitor cells.
A method of increasing the number of dopaminergic neurons in a patient suffering from Parkinson's disease or Parkinsonian disorders comprising the step of infusing the central nervous system of said patient with an amount of PDGF-BB of between 0.5 ng/kg/day to 500 ng/kg/day to increase the number of dopaminergic neurons.
A method of treating a patient with Parkinson's disease or Parkinsonian disorders comprising administering PDGF-BB in vivo directly to the central nervous system of said patient, wherein the PDGF-BB is administered in an amount of between 0.1 ng/kg/day to 1 μg/kg/day.
A method for inducing the in situ proliferation or differentiation of neural stem cells or neural progenitor cells located in a neural tissue of a human, the method comprising administering an amount of PDGF-BB of between 0.1 ng/kg/day to 1 μg/kg/day, to the neural tissue to induce the proliferation or differentiation of the neural stem cells or neural progenitor cells.
A method of increasing the number of dopaminergic neurons in a patient suffering from Parkinson's disease or Parkinsonian disorders comprising the step of infusing the central nervous system of said patient with an amount of PDGF-BB of between 0.1 ng/kg/day to 1 μg/kg/day to increase the number of dopaminergic neurons.
Dependencies are inferred from the claim text.