US 7,981,444 B2Granted

Dendritic polymers with enhanced amplification and interior functionality

AssigneeDendritic Nanotechnologies, Inc.

InventorsDonald A. Tomalia, Douglas R. Swanson, Baohua Huang, Veera Reddy Pulgam

Life of this patent

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Abstract

Poly(ester-acrylate) and poly(ester/epoxide) dendrimers. These materials can be synthesized by utilizing the so-called “sterically induced stoichiometric” principles. The preparation of the dendrimers is carried out by reacting precursor amino/polyamino-functional core materials with various branch cell reagents. The branch cell reagents are dimensionally large, relative to the amino/polyamino-initiator core and when reacted, produce generation=1 dendrimers directly in one step. There is also a method by which the dendrimers can be stabilized and that method is the reaction of the dendrimers with surface reactive molecules to pacify the reactive groups on the dendrimers.

Claims33

Dependent claims

A dendritic polymer of Formula (I):

wherein:
(C) means a core;
(FF) means a focal point functionality component of the core;
y is 0 or 1:
(BR) means a branch cell, which if p is greater than 1 (BR) may be the same or a different moiety;
p is the total number of branch cells (BR) in the dendrimer and is an integer from 1 to 2000 derived by
p
=
Total
⁢
⁢
#
⁢
⁢
of
⁢
⁢
(
BR
)
=
(
N
b
G
⁢
⁢
1
N
b
+
N
b
G
⁢
⁢
2
N
b
+
N
b
G
⁢
⁢
3
N
b
+
…
⁢
⁢
N
b
G
⁢
⁢
i
N
b
)
N
c
=
(
∑
x
=
0
x
=
i
-
1
⁢
⁢
N
b
x
)
N
(IF) means interior functionality, which if q is greater than 1 (IF) may be the same or a different moiety;
q is independently 0 or an integer from 1 to 2000;
(EX) means an extender, which if m is greater than 1 (EX) may be the same or a different moiety;
m is independently 0 or an integer from 1 to 1000;
(TF) means a terminal functionality, which if z is greater than 1 (IF) may be the same or a different moiety;
z means the number of surface groups from 1 to the theoretical number possible for the (BR) for a given generation (G) and is derived by
z=NcNbG;
G is number of concentric branch cell shells surrounding the core, where the upper limit is the attained at the deGennes dense-packed stage;
Nb is branch cell multiplicity;
and
Nc is core multiplicity and is an integer from 1 to 1000;
and
with the proviso that at least one of (EX) or (IF) is present.

91 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/594,776Filed 20 Apr 2005 · us provisional application
Priority: 20 Apr 2004
Published: US 2007/0244296 A118 Oct 2007
Granted: 19 Jul 2011
Term ends: Not estimatedThe source records don’t support an estimate.

Classification9 codes

C08G 83/003
Dendritic macromolecules: dendrimers
A61P 29/00
Non-central analgesic, antipyretic or antiinflammatory agents
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
C08G 59/1477
With organic low-molecular-weight compounds: containing nitrogen