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US 7,981,362 B2Granted
Modular assay plates, reader systems and methods for test measurements
AssigneeMeso Scale Technologies, LLC.
InventorsEli Glezer, Kent Johnson, Bandele Jeffrey-Coker, Alan Kishbaugh, Charles Clinton
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Abstract
Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
Claims45
An assay module having an array of wells with integrated electrodes, said module comprising
- (a) a module lip and a snap fit element extending from said module, said snap fit element positioned below said lip, wherein said lip and said snap fit element are configured to engage a plate frame of a multi-well plate;
- (b) a module top having a plurality of through-holes that define the walls of said array of wells;
- and
- (c) a module bottom defining the bottom of said array of wells.
1 more element
A method for carrying out an electrode induced luminescence assay comprising:
- (a) introducing one or more samples into one or more wells of a multi-well plate comprising:
- (i) one or more multi-well assay modules, said modules comprising a module lip and a snap fit element extending from said module, said snap fit element positioned below said lip, wherein said lip and said snap fit element are configured to engage a plate frame of a multi-well plate, said modules each having an array of wells with integrated electrodes;
- and (ii) a plate frame defining one or more apertures for receiving and holding said multi-well assay modules;
- and
- (b) applying an electrical potential to said electrodes and measuring luminescence produced in said wells.
2 more elements
A method for carrying out an electrode induced luminescence assay comprising:
- (a) introducing one or more samples into one or more wells of one or more assay modules, said modules comprising a module lip and a snap fit element extending from said module, said snap fit element positioned below said lip, wherein said lip and said snap fit element are configured to engage a plate frame of a multi-well plate, said modules having arrays of wells with integrated electrodes;
- (b) inserting said assay modules into a plate frame that defines one or more apertures for receiving and holding said multi-well assay modules;
- and
- (c) applying an electrical potential to said electrodes and measuring luminescence produced in said wells.
1 more element
Dependencies are inferred from the claim text.