Process for the preparation of faropenem
AssigneeRanbaxy Laboratories Limited
InventorsNeela Praveen Kumar, Mohan Prasad
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Abstract
The present invention is related to processes for the preparation of faropenem, which comprises treating the compound of Formula II, with an alkali metal salt of a substituted or unsubstituted C5-10 carboxylic acid and a catalytic amount of a palladium complex in the presence of an organic solvent, followed by the treatment of the reaction mixture of with water and a water miscible solvent, and isolating a hydrate of an alkali metal salt of faropenem from the reaction mass, wherein water is not removed from the reaction mixture in water treatment or isolation steps.
Claims10
A process for the preparation of a hydrate of an alkali metal salt of faropenem, wherein the process comprises,
- a) treating the compound of Formula II,
- wherein R1 is C1-C8 alkyl, C3-C8 alkenyl, C7-C19 aralkyl, or C6-C12 aryl, with an alkali metal salt of a substituted or unsubstituted C5-10 carboxylic acid and a catalytic amount of a palladium complex in the presence of an organic solvent;
- b) treating the reaction mixture of step a) with water and a water miscible solvent,
- c) isolating a hydrate of an alkali metal salt of faropenem from the reaction mass thereof,
- wherein water is not removed from the reaction mixture in step b) or c).
Dependencies are inferred from the claim text.