c-MET modulators and method of use

A compound of formula IVc:

• wherein:
• J1 is ═CH—;
• J2 is ═C(R1)—;
• J3 is ═N—;
• J4 is ═N—;
• J5 is C—H or C—F;
• Z is O;
• R1 is independently selected from halogen, trihalomethyl, —CN, —NO2, —OR20, —N(R20)R20, —S(O)0-2R20, —SO2N(R20)R20, —CO2R20, —C(O)N(R20)R20, —N(R20)SO2R20, —N(R20)C(O)R20, —NHCO2R20, —C(O)R20, optionally substituted C1-6alkyl, optionally substituted aryl, optionally substituted aryl C1-6alkyl optionally substituted heterocyclyl, and optionally substituted heterocyclyl C1-6alkyl;
• R2 is H;
• each R3a is independently selected from —H, halogen, trihalomethyl, —CN, —NO2, —OR20, —N(R20)R20, —S(O)0-2R20, —SO2N(R20)R20, —CO2R20, —C(O)N(R20)R20, —N(R20)SO2R20, —N(R20)C(O)R20, —NHCO2R20, —C(O)R20, optionally substituted C1-6alkyl, and optionally substituted heterocyclyl;
• each R20 is independently —H, optionally substituted C1-6alkyl, optionally substituted aryl, optionally substituted aryl C1-6alkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl C1-6alkyl;
• or two of R20, when taken together with a common nitrogen to which they are attached, can form an optionally substituted five- to seven-membered heterocyclyl, said optionally substituted five- to seven-membered heterocyclyl optionally containing at least one additional annular heteroatom selected from N, O, S, and P;
• and
• each R70 is independently selected from —H, halogen, trihalomethyl, —CN, —NO2, —OR20, —N(R20)R20, —S(O)0-2R20, —SO2N(R20)R20, —CO2R20, —C(O)N(R20)R20, —N(R20)SO2R20, —N(R20)C(O)R20, —NHCO2R20, —C(O)R20, optionally substituted C1-6alkyl, optionally substituted aryl, optionally substituted aryl C1-6alkyl, optionally substituted heterocyclyl, and optionally substituted heterocyclyl C1-6alkyl.