Modulators of ATP-binding cassette transporters

A compound having formula IIIB:

• wherein:
• X9 is CH2 or CF2;
• m is 0 to 4;
• Ht1 is a 5-membered heteroaromatic ring containing 1-4 heteroatoms selected from O, S, N, or NH;
• x, q, and z is independently 0-5;
• X—Rx is H or unsubstituted alkyl;
• Z—Rz is halo, C1-C8 aliphatic, OR6, SO2R6, CF3, or two occurrences of Z—Rz taken together with the atom(s) to which they are bound form a ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• L is CHRL;
• RL is —OR′ or —N(R′)2;
• Ar is phenyl or a six-membered heteroaromatic ring;
• R′ is independently selected from hydrogen or an optionally substituted group selected from a C1-C8 aliphatic group, or a 3-8-membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• or two occurrences of R′ are taken together with the atom(s) to which they are bound to form an optionally substituted 3-12 membered saturated, partially unsaturated, or fully unsaturated monocyclic or bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• and
• R6 is H or aliphatic.