Hepatitis-C virus testing
AssigneeCommon Services Agency
InventorsPeter Simmonds, Shui-Wan Chan, Peng Lee Yap
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Abstract
New styles of hepatitis C virus (HCV), referred to as HCV-3 and HCV-4, have been identified and sequenced. Antigenic regions of HCV-2, HCV-3 and HCV-4 polypeptides have been identified. Immunoassays for HCV and antibodies thereto are described, which allow more complete screening of blood samples for HCV, and allow HCV genotyping.
Claims11
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:15.
An immunoassay device that comprises a solid substrate having attached thereto a polypeptide comprising the amino acid sequence of SEQ ID NO:15.
A fusion polypeptide comprising a first polypeptide operably linked to a heterologous protein or fragment, wherein said first polypeptide comprises the polypeptide set forth in SEQ ID NO:15.
A fusion polypeptide comprising at least two polypeptides wherein one polypeptide is SEQ ID NO:15, and wherein said at least two polypeptides are operably linked together.
A composition comprising a polypeptide consisting of SEQ ID NO:15 and a pharmaceutically acceptable carrier.
A method for detecting HCV infection in a mammal, comprising:
- a) obtaining a blood sample from said mammal;
- b) contacting said blood sample with at least one polypeptide consisting of SEQ ID NO:15;
- and,
- c) detecting if an antibody present in said blood sample is bound to said polypeptide.
Dependencies are inferred from the claim text.