Methods and compositions for preventing and treating solid tumors
AssigneeThe Board of Trustees of the University of Illinois
InventorAnil Gulati
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Abstract
Compositions and methods of preventing or treating a breast cancer are disclosed. The composition and method can utilize an endothelin B agonist and a chemotherapeutic agent as active ingredients to treat a solid tumor in mammals, including humans. Alternatively, the composition and method can utilize an endothelin B antagonist and an optional angiogenesis inhibitor to treat a solid tumor in mammals, including humans.
Claims14
A method of treating a breast tumor comprising administering to a mammal in need thereof a therapeutically effective amount of an endothelin B receptor agonist and a therapeutically effective amount of a chemotherapeutic agent, wherein the endothelin B receptor agonist is IRL 1620.
A composition comprising a chemotherapeutic agent, and a second agent that selectively increases blood flow to a solid tumor, wherein said second agent is IRL 1620, and an optional excipient.
An article of manufacture comprising:
- (a) a packaged composition comprising an IRL 1620;
- (b) a packaged composition comprising a chemotherapeutic agent;
- (c) an insert providing instructions for increasing blood flow to a solid tumor by simultaneous or sequential administration of (a) and (b) to treat the solid tumor in a mammal;
- and (d) a separate container for (a), (b), and (c).
An article of manufacture comprising:
- (a) a packaged composition comprising an IRL 1620 and a chemotherapeutic agent;
- (b) an insert providing instructions for increasing blood flow to a solid tumor by administration of (a) to treat the solid tumor in a mammal;
- and (c) a separate container for (a) and (b).
Dependencies are inferred from the claim text.