Process for the purification of Ropinirole hydrochloride
AssigneeAlembic Limited
InventorsPandurang Balwant Deshpande, Ashok Prataprai Shanishchara, Trushar Rajanikant Shah, Hitarth Harshendu Acharya, Parven Kumar Luthra
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Abstract
An improved process is described for the purification of ropinirole hydrochloride. The process includes (i) dissolving ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.
Claims4
A process for purification of Ropinirole hydrochloride of formula (Ia)
- comprising steps of:
- (i) dissolving Ropinirole hydrochloride in water;
- (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal;
- (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base;
- and
- iv) treating the free base obtained in step (iii) with ethanolic HCl to give Ropinirole hydrochloride.
Dependencies are inferred from the claim text.