Cardiac muscle function and manipulation
AssigneeZensun (Shanghai) Sci. & Tech. Ltd.
InventorMingdong Zhou
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Abstract
A method of causing cardiomyocyte growth and/or differentiation, the method comprising exposing a cardiomyocyte to neuregulin (NRG) thereby activating the MAP kinase pathway in the cardiomyocyte and causing growth and/or differentiation of the cardiomyocyte. Use of neuregulin, neuregulin polypeptide, neuregulin derivatives, or compounds which mimic the activities of neuregulins in the treatment or management of heart disease and heart failure in a mammal.
Claims51
A method for providing a therapeutic treatment for heart failure in a mammal in need thereof, comprising administering an effective amount of polypeptide consisting of the amino acid sequence of SEQ ID NO:2 to the mammal, wherein the heart failure is associated with cardiomyopathy, hypertension or myocarditis.
A method for providing a therapeutic treatment for heart failure in a mammal in need thereof, comprising administering an effective amount of polypeptide consisting of the amino acid sequence of SEQ ID NO:2 to the mammal, wherein the heart failure is characterized by the heart not pumping blood at the rate needed for the requirements of metabolizing tissues.
A method for improving cardiac function in a mammal with heart failure, comprising administering an effective amount of polypeptide consisting of the amino acid sequence of SEQ ID NO:2 to the mammal.
Dependencies are inferred from the claim text.