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US 7,960,526 B2Granted
Colorimetric-oxycarbonyl protecting groups for use in organic syntheses
AssigneeBerry and Associates, Inc.
InventorsJohn C. Hodges, Yam Foo Poon, William H. Pearson
Life of this patent
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Abstract
The present invention provides for reagents for the introduction of colorimetric-oxycarbonyl protecting groups, compounds bearing colorimetric-oxycarbonyl protecting groups, and the use thereof in solid-supported organic syntheses of oligonucleotides, polypeptides, polysaccharides, and combinatorial libraries.
Claims20
A compound of Formula I
- wherein:
- R1, R2, and R3 are each independently H, Br, Cl, Fl, R, or OR wherein R is C1-C6-alkyl;
- X is selected from the group consisting of an acyl-leaving group, a C1-C6-alkyl ester of an amino acid, an active ester of an amino acid, an amino acid, an amino alcohol, an amino ether, an amino alcohol-O-phosphoramidite, an amino-nucleoside, an amino-nucleoside-O-phosphoramidite, and a diamine;
- n is an integer that is selected from 0 to 8;
- Z1 and Z2 are each independently C1-C6-alkyl, or aryl;
- or a salt thereof.
3 more elements
A compound of formula of the following formula:
- wherein
- Z1 and Z2 are each independently aryl;
- and
- X is selected from the group consisting of an acyl-leaving group, a C1-C6-alkyl ester of an amino acid, an active ester of an amino acid, an amino acid, an amino alcohol, an amino ether, an amino alcohol-O-phosphoramidite, an amino-nucleoside, an amino-nucleoside-O-phosphoramidite, and a diamine;
- or a salt thereof.
2 more elements
Dependencies are inferred from the claim text.