Activin-ActRIIa antagonists and uses for decreasing or inhibiting FSH secretion
AssigneeAcceleron Pharma Inc.
InventorsJohn Knopf, Jasbir Seehra, Matthew L. Sherman
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Abstract
In certain aspects, the present invention provides compositions and methods for decreasing FSH levels in a patient. The patient may, for example, be diagnosed with an FSH-related disorder or desire to delay or inhibit germ cell maturation.
Claims40
A method for decreasing follicle-stimulating hormone (FSH) levels in a human subject, the method comprising administering to a subject in need thereof an amount of an activin receptor type IIa-immunoglobulin Fc domain (ActRIIa-Fc) fusion protein effective to reduce FSH levels in the subject, wherein the ActRIIa-Fc fusion protein comprises an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:3, wherein the amount administered results in an ActRIIa-Fc serum concentration of at least 1000 ng/mL, and wherein the ActRIIa-Fc fusion protein binds to activin.
Dependencies are inferred from the claim text.