US 7,959,916 B2Granted

Negative immunomodulation of immune responses by ERp5

AssigneeFred Hutchinson Cancer Research Center

InventorsThomas Spies, Veronika Groh-Spies

Life of this patent

Estimating the term…

Abstract

The present invention relates to methods of treating immune disorders and cancers. In particular the invention provides methods of inhibiting the negative immunomodulatory effects of ERp-5 on T cells and dendritic cells, in conjunction with other surface receptors.

Claims4

Dependent claims

A method of inhibiting shedding of MIC polypeptides from a MIC expressing cancer cell comprising contacting a MIC expressing cancer cell with an anti-MIC α3 domain antibody.

Dependencies are inferred from the claim text.

Facts

Application: 12/108,069Filed 23 Apr 2008 · us provisional application
Priority: 23 Apr 2007
Published: US 2009/0169552 A12 Jul 2009
Granted: 14 Jun 2011
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

C12N 15/1137
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming…: against enzymes
A61P 35/00
Antineoplastic agents
A61P 37/02
Drugs for immunological or allergic disorders: immunomodulators
A61P 37/06
Immunomodulators: immunosuppressants, e.g. drugs for graft rejection

Family

Application60/913,467Us provisional application · filed 23 Apr 2007
US 2009/0169552 A1Pre-grant publication · published 2 Jul 2009
US 7,959,916 B2This patent

From the US filing history. Foreign family members aren’t listed.

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