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US 7,956,195 B2Granted
Process for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane-carboxylates
AssigneeAbbott Laboratories
InventorsThomas D. Gordon, Grier A. Wallace, Martin E. Hayes, Kirill A. Lukin, Lei Wang, Dilinie P. Fernando
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Abstract
The present invention discloses processes for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane-carboxylates.
Claims4
A process for the preparation of a mixture of compounds of Formula 7a and Formula 7b
- comprising the steps of reacting the mixture of compounds of Formula 6a and Formula 6b
- with potassium carbonate and an alkylating agent to give a mixture of compounds of Formula 7a and Formula 7b
A process for isolating a compound of Formula 8
- comprising the steps of dissolving the mixture of compounds of Formula 7a and Formula 7b
- in hot acetonitrile and then cooling the solution to give a compound of Formula 8
A process for the preparation of a compound of Formula 9
- comprising the steps of hydrolizing Formula 8
- with an aqueous base to give a compound of Formula 9
A process of isolating a compound of Formula 11a
- comprising the step of filtering the mixture of compounds of Formula 11a and Formula 11b
- to isolate a compound of Formula 11a
Dependencies are inferred from the claim text.