Norovirus vaccine formulations
AssigneeLigocyte Pharmaceuticals, Inc.
InventorsCharles Richardson, Thomas S. Vedvick, Thomas R. Foubert, William T. Tino
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Abstract
The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.
Claims37
An immunogenic composition comprising at least one Norovirus antigen, chitosan, sucrose, and at least one adjuvant, wherein said antigen comprises Norovirus virus-like particles (VLPs) and the adjuvant is not a bacterial exotoxin, and wherein the composition is formulated as a stable dry powder such that the percent aggregation of VLPs remains relatively constant or decreases when measured over a twelve month period.
Dependencies are inferred from the claim text.