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US 7,947,680 B2Granted
Adamantyl diamide derivatives and uses of same
AssigneeH. Lundbeck A/S
InventorsHermogenes N. Jimenez, Guiying Li, Dario Doller, Michel Grenon, Andrew D. White, Gil Ma, Maojun Guo
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Abstract
The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.
Claims18
A compound of formula (I):
- wherein:
- R1 is C2-C6alkyl, cycloalkyl, ketocycloalkyl, heterocyclyl, aryl or heteroaryl, wherein each is optionally mono-, di-, or tri-substituted independently with alkyl, alkoxy, halogen, cyano, nitro, trifluoroalkyl, amino, alkylamino, dialkylamino, acyl, aryl, heteroaryl, heterocyclyl, heterocyclyl-R3, —NHR3, —N(alkyl)R3, —C(O)NHR3, —C(O)N(alkyl)R3, —NHC(O)R3, —N(alkyl)C(O)R3, —OH or —OR3;
- and
- R2 is alkyl, cycloalkyl, ketocycloalkyl, heterocyclyl, aryl or heteroaryl, wherein each is optionally mono-, di-, or tri-substituted independently with alkyl, alkoxy, halogen, cyano, nitro, trifluoroalkyl, amino, alkylamino, dialkylamino, acyl, aryl, heteroaryl, heterocyclyl, heterocyclyl-R3, —NHR3, —N(alkyl)R3, —C(O )NHR3, —C(O)N(alkyl)R3, —NHC(O)R3, —N(alkyl)C(O)R3, —OH or —OR3;
- wherein:
- R3 is C1-C6alkyl or C1-C6cycloalkyl, which is optionally substituted with halogen, C1-C3alkoxy, OH, —CN, —NH2, —NH(C1-C3alkyl), —N(C1-C3alkyl)2, C1-C3alkylheterocyclyl, C1-C3alkylcarbamate, —C(O)NH(C1-C3alkyl), —C(O)N(C1-C3alkyl)2, —NHC(O)—C1-C3alkyl, —N(C1-C3alkyl)-C(O)—C1-C3alkyl, OH, or —O—C1-C6alkyl;
- with the proviso that the compound of formula (I) is not:
- N,N′-(1,3-adamantylene)bis(3-methoxy-benzamide);
- N,N′-(1,3-adamantylene)bis(4-ethoxy-benzamide);
- N,N′-(1,3-adamantylene)bis(4-methoxy-benzamide);
- N,N′-(1,3-adamantylene)bis(3,4,5-trimethoxybenzamide);
- N,N′-(1,3-adamantylene)bis(2-iodo-benzamide);
- N,N′-(1,3-adamantylene)bis-benzamide;
- N,N′-(1,3-adamantylene)bis(3-nitrobenzamide);
- and
- N,N′-(1,3-adamantylene)bis-(3-pyridinecarboxamide);
- or
- a pharmaceutically acceptable salt thereof.
15 more elements
Dependencies are inferred from the claim text.