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US 7,947,307 B2Granted
Methods and compositions for imaging
AssigneeMount Sinai School of Medicine of New York University
InventorsEdward A. Fisher, Zahi A. Fayad, Gwendalyn Randolph, Jonathan Feig, Eugene Trogan
Life of this patent
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Abstract
The present invention is directed to compositions useful as imaging agents for use in monitoring atherosclerotic plaque regression using, for example, MRI, CT, Gamma-scintigraphy, or optical imaging techniques. Methods and compositions of using the same are described.
Claims52
A synthetic nanoparticle, said synthetic nanoparticle comprising:
- at least one apolipoprotein that is not an apoB lipoprotein, at least one amphipathic lipid, and at least one metallic or non-metallic contrast agent conjugated to a component of said nanoparticle, said at least one metallic or non-metallic contrast agent being present in an amount between 5% to about 50% (w/w) of said nanoparticle, and said synthetic nanoparticle having a diameter from about 5 nm to about 50 nm,
- and wherein said nanoparticle further comprises a C—C chemokine receptor type 7 (CCR7) targeting moiety for monitoring atherosclerosis.
Dependencies are inferred from the claim text.