Compositions and methods to control abnormal cell growth

A method of synthesizing a compound having the following generic formula:

• wherein L is a C1-C4 straight alkane;
• wherein R1, R2 and R3 are independently hydrogen or a C1-C4 straight alkane;
• and wherein Z− is Cl− or I−, the method comprising the steps of:
• a) contacting 2′-iodobenzoic acid with p-thiocresol to form 2-((4-methylphenyl)thio)-benzoic acid;
• b) heating 2-((4-methylphenyl)thio)-benzoic acid in the presence of polyphosphoric acid to form 2-methyl-9H-thioxanthen-9-one,
• c) contacting 2-methyl-9H-thioxanthen-9-one with a source of bromide to form 2-(bromomethyl)-9H-thioxanthen-9-one;
• d) contacting 2-(bromomethyl)-9H-thioxanthen-9-one with 2′-dialkyl aminoethanol or 2′ dialkyl aminopropanol to form 2-{(2-(dialkylamino)ethoxy)methyl}-9H-thioxanthen-9-one or 2-{(2-(dialkylamino)propoxy)methyl}-9H-thioxanthen-9-one;
• and
• e) contacting 2-{(2-(dialkylamino)ethoxy)methyl}-9H-thioxanthen-9-one or 2-{(2-(dialkylamino)propoxy)methyl}-9H-thioxanthen-9-one with an alkyl iodide or an alkyl chloride to form a compound having the formula of Formula I.

A compound represented by the formula:

• wherein R1 and R3-8 are independently hydrogen, C1-C26 straight, branched or cyclic alkanes or alkenes, aromatic hydrocarbons, alcohols, ethers, aldehydes, ketones, carboxylic acids, amines, amides, nitriles, or five- and/or six-membered heterocyclic moieties;
• wherein R2 is hydrogen or —CH3;
• wherein Y is —S—, —Se—, —NH—, or —O—;
• wherein L is a C1-C4 straight alkane, alkene, thiol, ether, or amine;
• wherein R11, R12 and R13 are independently C1-Ca straight alkanes, alkenes, thiols, amines, ethers or alcohols;
• wherein Z− is Cl−, Br− or I−;
• and
• wherein the compound may be administered in a suitable carrier at a therapeutically effective dose to an untreated or treated mammal or human with cancer to reduce tumor size or to treat loss of lean body weight as a consequence of composition-induced reduction in tumor size or both.

A method of synthesizing a compound having the following generic formula:

• wherein R1 is hydrogen or —CH3;
• wherein R2, R3 and R4 are each independently C1-C4 straight alkanes or alkenes;
• and wherein Z− is Cl−, Br− or I−, the method comprising the steps of:
• a) reacting thioxanthone or 2-methylthioxanthone with a reagent formed by reacting magnesium with dibromide methane and an dialkylaminopropyl chloride to form 9-(3-(dialkylamino)propyl)-9H-thioxanthen-9-ol or 9-(3-(dialkylamino)propyl)-2-methyl-9H-thioxanthen-9-ol;
• b) refluxing with constant mixing of 9-(3-(dialkylamino)propyl)-9H-thioxanthen-9-ol or 9-(3-(dialkylamino)propyl)-2-methyl-9H-thioxanthen-9-ol in the presence of an aqueous acid to form N,N-dialkyl-N-(3-(9H-thioxanthen-9-ylidene)-propyl amine or N,N-dialkyl-N-(3-(2-methyl-9H-thioxanthen-9-ylidene)-propyl amine;
• and
• c) contacting N,N-dialkyl-N-(3-(9H-thioxanthen-9-ylidene)-propyl amine or N,N-dialkyl-N-(3-(2-methyl-9H-thioxanthen-9-ylidene)-propyl amine with a halide compound having the structure R—X, wherein R is an alkyl or allyl group and X is either Cl−, Br− or I− to form a compound having the formula of Formula II.