Osteogenic implant matrices and endosseous tooth implants with improved osteointegration properties
AssigneeImmundiagnostik AG
InventorFranz Paul Armbruster
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Abstract
Implant articles with improved osseointegrating properties, osteogenic implant materials, and process of inducing differentiation of mesenchymal stem cells, proliferation of osteoblast and attachment of cells to implant surface, comprising the step of impregnating the surface with a solution containing osteoactive bone sialoprotein, recombinant human bone sialoprotein, recombinant His-Myc-Ek-BSP or substantive fragments thereof that have not been in contact with serum containing complement factor H or any other BSP processing material.
Claims9
Implant material comprising a substrate selected from the group consisting of titanium, titanium oxide, zirconium, zirconium oxide, tantalum, tantalum oxide, niobium, niobium oxide, magnesium, alloys thereof, and stainless steel, said substrate having been treated with recombiant bone sialoprotein that cannot bind complement factor H or substantive fragments thereof that cannot bind complement factor H.
Process of improving the osteointegration properties of implant articles, comprising the step of impregnating the surface of the article with a solution containing recombinant bone sialoprotein that cannot complement factor H, or substantive fragments thereof that cannot bind complement factor H.
Process of inducing differentiation of mesenchymal stem cells, proliferation of osteoblast and attachment of cells to an implant material, comprising the step of impregnating the surface with a solution containing recombinant bone sialoprotein that cannot bind complement factor H, or substantive fragments thereof that cannot bind complement factor H.
Dependencies are inferred from the claim text.