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US 7,943,168 B2Granted
Nanoparticle delivery systems comprising a hydrophobic core and a lipid/surfactant layer comprising a membrane-lytic peptide
AssigneeWashington University
InventorsPaul Schlesinger, Neelesh Soman, Gregory Lanza, Samuel A. Wickline
Life of this patent
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Abstract
Compositions which comprise emulsions of nanoparticles for delivery of membrane-integrating peptides are described. The nanoparticles comprise a liquid hydrophobic core coated with a lipid/surfactant layer which contains the membrane-integrating peptides. Methods to use such compositions are also described.
Claims11
A composition comprising nanoparticles, which nanoparticles comprise a liquid hydrophobic core coating with a lipid/surfactant layer, wherein said lipid/surfactant layer contains at least one membrane-integrating peptide, which is a membrane-lytic peptide.
Dependencies are inferred from the claim text.