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US 7,939,287 B2Granted
Methods of identifying a subject having or at risk of having or developing coronary artery disease
AssigneeThe Regents of the University of California
InventorsSotirios Tsimikas, Joseph Witztum
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Abstract
Provided herein are compositions and methods for identifying individuals at risk for developing coronary artery disease (CAD).
Claims16
A method for determining a subject's predisposition to a coronary artery disease, the method comprising:
- a) determining the subject's plasma OxPL level, wherein the OxPL is associated with apolipoprotein B-100 (apoB) particles;
- b) determining the subject's Lp-PLA2 mass or activity;
- and
- c) correlating a) and b), wherein increased levels of OxPL and Lp-PLA2 are indicative of a predisposition to the coronary artery disease.
1 more element
A method of identifying a subject having or at risk of having or developing a coronary artery disease , comprising
- (1)measuring in a sample from the subject at least:
- (a) Lp-PLA2 or sPLA2 activity or mass in the sample;
- and
- (b) oxidized phospholipids (OxPL) on apolipoprotein B-100 particles (apoB), and
- (2) correlating the measurements of (1) (a) and (1) (b) with a risk of having or developing a coronary artery disease.
2 more elements
A method of identifying a subject having or at risk of having or developing a coronary artery disease, comprising
- (1) measuring in a sample from the subject at least:
- (a) Lp-PLA2 activity or mass in the sample,
- wherein the Lp-PLA2 activity is measured in a fluorimetric assay comprising a substrate for Lp-PLA2;
- and
- (b) oxidized phospholipids (OxPL) on apolipoprotein B-100 particles (apoB), and
- (2) correlating the measurements of (1)(a) and (1)(b) with a risk of having or developing a coronary artery disease.
3 more elements
Dependencies are inferred from the claim text.