Nucleic acids and proteins from Streptococcus groups A & B
AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsJohn Telford, Vega Masignani, Maria Scarselli, Guido Grandi, Herve Tettelin, Claire Fraser
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Abstract
The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
Claims40
A recombinant expression cassette comprising an isolated nucleic acid molecule which encodes a protein which comprises the amino acid sequence shown in SEQ ID NO:8780.
A recombinant expression cassette comprising an isolated nucleic acid molecule which encodes a polypeptide with at least 85% amino acid sequence identity to SEQ ID NO:8780.
A composition comprising an isolated protein which comprises the amino acid sequence shown in SEQ ID NO:8780.
A composition comprising two or more isolated proteins, wherein one of the two proteins comprises the amino acid sequence shown in SEQ ID NO:3922 and the other of the two proteins comprises the amino acid sequence shown in SEQ ID NO:8780.
A composition comprising an isolated polypeptide which comprises an amino acid sequence with at least 85% amino acid sequence identity to SEQ ID NO:8780.
A purified protein comprising the amino acid sequence shown in SEQ ID NO:8780.
A purified protein, wherein the amino acid sequence of the purified protein is at least 85% identical to the amino acid sequence shown in SEQ ID NO:8780.
A method of raising an immune response in a patient against a group B Streptococcus which comprises a protein comprising the amino acid sequence SEQ ID NO:8780, comprising administering to the patient an effective amount of a composition comprising (i) an isolated protein comprising the amino acid sequence SEQ ID NO:8780 and (ii) an adjuvant.
A method of raising an immune response in a patient against a group B Streptococcus which comprises a protein comprising the amino acid sequence SEQ ID NO:8780, comprising administering to the patient an effective amount of a composition comprising (i) a purified protein comprising an amino acid sequence which is at least 85% identical to the amino acid sequence shown in SEQ ID NO:8780 and (ii) an adjuvant.
Dependencies are inferred from the claim text.