Back to results
US 7,939,061 B2Granted
Cell and enzyme compositions for modulating bile acids, cholesterol and triglycerides
AssigneeMicropharma Limited
InventorsSatya Prakash, Mitchell Lawrence Jones
Life of this patent
Estimating the term…
Abstract
The invention relates to immobilized or encapsulated enzyme and/or cells to lower bile acids and cholesterol. The invention also relates to methods of quantitatively measuring bile acids. The invention provides a composition for decreasing the amount of a target compound in the gastrointestinal tract of an animal, comprising: a) a biologically active agent which decreases the amount of the target compound; b) a retainer for retaining the biologically active agent by contacting the agent to limit movement of the agent; and c) a carrier.
Claims32
A composition comprising:
- a. a bile-permeable microcapsule comprising a cell expressing a bile acid deconjugating enzyme in an amount sufficient to deconjugate bile in the microcapsule in the small intestine;
- and
- b. a carrier;
- wherein the bile-permeable microcapsule permits entry of bile and retains at least a portion of bile acid precipitate produced from the bile by the bile acid deconjugating enzyme.
1 more element
Dependencies are inferred from the claim text.