Compositions and methods for treating inflammation and auto-immune diseases
AssigneeThe Johns Hopkins University
InventorLieping Chen
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Abstract
Compositions containing soluble B7-H4 (sH4) antagonists in an amount effective to reduce, inhibit, or mitigate an inflammatory response in an individual and methods for the treatment or prophylaxis of inflammatory disorders and autoimmune diseases or disorders are provided. Soluble H4 has been discovered to interfere with B7-H4 activity including B7-H4's activity as an inhibitor of T cell immunity. Thus, interference of sH4 biological activity is an effective method to restore B7-H4 activity and thereby provide an effective method for treating inflammatory diseases or disorders including autoimmune diseases or disorders. B7-H4Ig could also work as an agonist to suppress both humoral and cellular autoimmunity.
Claims16
A pharmaceutical composition dosage unit comprising an antibody or antibody fragment that selectively binds an epitope on soluble B7-H4 masked or absent on membrane bound B7-H4;
- wherein the antibody or antibody fragment is present in the dosage unit in an amount effective to reduce or inhibit one or more symptoms of an inflammatory response in an individual in need thereof,
- and a pharmaceutically acceptable carrier for administration by injection of the dosage unit.
Dependencies are inferred from the claim text.