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US 7,928,237 B2Granted
Fused ring azadecalin glucocorticoid receptor modulators
AssigneeCorcept Therapeutics, Inc.
InventorsRobin D. Clark, Nicholas C. Ray, Paul M. Blaney, Christopher A. Hurley, Karen Williams
Life of this patent
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Abstract
The present invention provides a novel class of fused ring azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
Claims10
A compound having the formula
- wherein
- L1 and L2 are members independently selected from a bond and unsubstituted alkylene;
- R1 is a member selected from unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted heterocycloalkyl, —OR1A, —NR1CR1D, —C(O)NR1CR1D, and —C(O)OR1A, wherein
- R1A is a member selected from hydrogen, unsubstituted alkyl and unsubstituted heteroalkyl,
- R1C and R1D are members independently selected from unsubstituted alkyl and unsubstituted heteroalkyl,
- wherein R1C and R1D are optionally joined to form an unsubstituted ring with the nitrogen to which they are attached, wherein said ring optionally comprises an additional ring nitrogen;
- R2 has the formula:
- wherein
- R2G is a member selected from hydrogen, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, —CN, and —CF3;
- J is phenyl;
- t is an integer from 0 to 5;
- X is —S(O2)—;
- and
- R5 is phenyl optionally substituted with 1-5 R5A groups, wherein
- R5A is a member selected from hydrogen, halogen, —OR5A1, —S(O2)NR5A2R5A3, —CN, and unsubstituted alkyl, wherein
- R5A1 is a member selected from hydrogen and unsubstituted alkyl, and
- R5A2 and R5A3 are members independently selected from hydrogen and unsubstituted alkyl.
14 more elements
Dependencies are inferred from the claim text.