Feline IL-18 proteins
AssigneeHeska Corporation
InventorRamani S. Wonderling
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Abstract
The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain proteins. The present invention also includes feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine interleukin-12 single chain nucleic acid molecules encoding such proteins, antibodies raised against such proteins and/or inhibitors of such proteins or nucleic acid molecules. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and/or inhibitors, as well as their use to evaluate and regulate an immune response in an animal.
Claims6
An isolated protein comprising an amino acid sequence at least 95% identical to a polypeptide sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:5, SEQ ID NO:8 and SEQ ID NO:12,
- wherein said protein has IL-18 activity.
An isolated protein encoded by
- a nucleic acid sequence at least 95% identical to SEQ ID NO:1, SEQ ID NO:4, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:11, and SEQ ID NO:41,
- wherein said isolated protein has IL-18 activity.
An isolated protein consisting of an amino acid sequence at least 95% identical to a polypeptide sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:5, SEQ ID NO:8 and SEQ ID NO:12, wherein said protein has IL-18 activity.
Dependencies are inferred from the claim text.