Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors

A comestible composition comprising

• at least a sweet flavor entity selected from the group consisting of sucrose, sucralose, and combinations thereof;
• and
• a compound of structural Formula (IIc):
• or a pharmaceutically acceptable salt thereof, wherein:
• A is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, —CN, —OR9, —NR9COR10, —NHOR9,—NR9R10, —NR9CO2R10, —NR9CONR10R11, —NR9CSNR10R11, or —NR9C(═NH)NR10R11;
• R17 is hydrogen, alkyl, substituted alkyl;
• W is —S—;
• Y is —C(R26)—;
• Z is —C(R27)—;
• R26 is hydrogen, alkyl, substituted alkyl, —OR31, —CONR31R32, or —CO2R31;
• R27 is hydrogen, alkyl, substituted alkyl, —OR33, —CONR33R34, or —CO2R33 and
• R9, R10, R11, R31, R32, R33, and R34 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;
• alternatively R10 and R11, R31 and R32, or R33 and R34 together with the atoms to which they are bonded form a heterocycloalkyl or substituted heterocycloalkyl ring;
• wherein the substituted alkyl, substituted aryl, substituted arylalkyl, substituted heteroalkyl, substituted heteroaryl, substituted heteroarylalkyl, and substituted heterocycloalkyl each independently comprises one or more substituent groups selected from the group consisting of —Ra, halo, ═O, —ORb, —SRb, ═S, —NRcRc, ═NRb, ═N—ORb, trihalomethyl, —CN, —NO2, S(O)2Rb, —S(O)2NRb, —S(O)2ORb, —OS(O)2Rb, —OS(O)2ORb, —P(O)(ORb)(ORb), —C(O)Rb, —C(NRb)Rb, —C(O)ORb, —C(O)NRcRc, —C(NRb)NRcRc, —OC(O)Rb, —OC(O)ORb, —NRbC(O)Rb, —NRbC(O)ORb, —NRbC(O)NRcRc, —NRbC(NRb)Rb and —NRbC(NRb)NRcRc, where Ra is selected from the group consisting of alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl;
• each Rb is independently hydrogen or Ra;
• and each Rc is independently Rb or alternatively, the two Rcs are taken together with the nitrogen atom to which they are bonded form a 4-, 5-, 6- or 7-membered heterocycloalkyl.