Use of neuropeptides for traumatic cartilage injury
AssigneeWisconsin Alumni Research Foundation
InventorsRay Vanderby, Kelley W. Grorud
Life of this patent
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Abstract
Disclosed are a method and a corresponding pharmaceutical composition for treating damaged cartilage and subchondral bone. Neurogenic compounds in general and neuropeptides in particular have been found to be highly effective in stimulated repair of cartilage and bone damaged due to traumatic injury, ligament disease, and disuse. Preferred active ingredients for use in the method and corresponding pharmaceutical composition include calcitonin gene-related peptide (CGRP), cholecystokinin (CCK), dynorphin, enkephalin, galanin, neuropeptide Y (NPY), neurotensin, somatostatin, substance P (SP), thyrotropin-releasing hormone (TRH), vasoactive intestinal peptide (VIP).
Claims4
A method of treating traumatic cartilage injury, the method comprising administering to the subject an amount of a neuropeptide selected from the group consisting of calcitonin gene-related peptide (CGRP), eholecystokinin (CCK), dynorphin, enkephalin, galanin, neuropeptide Y (NPY), neurotensin, somatostatin, substance P (SP), thyrotropin-releasing hormone (TRH), vasoactive intestinal peptide (VIP), and combinations thereof, the amount being effective to stimulate repair of the injured cartilage.
Dependencies are inferred from the claim text.