Compositions and methods for immunodominant antigens of Mycobacterium tuberculosis
OwnerPhilip Felgner, Xiaowu Liang +1inventors
InventorsPhilip Felgner, Xiaowu Liang, Maria Laura Gennaro
Life of this patent
Estimating the term…
Abstract
Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen M. tuberculosis and their use in vaccines, therapeutic agents, and various diagnostic tests. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter.
Claims13
A method for the detecting presence of antibodies which specifically bind to antigens of M. tuberculosis and which are present in a bodily fluid sample, comprising contacting the sample with antigens of M. tuberculosis, wherein at least two of the antigens are encoded by nucleic acids Rv3874 (SEQ ID NO:547) and Rv0798c (SEQ ID NO:121), respectively, and detecting antibodies which bind to the antigens.
Dependencies are inferred from the claim text.