Universal, wireless, nano-optical voltmeters
AssigneeThe Regents of the University of Michigan
InventorsMartin A. Philbert, Katherine M. Tyner, Raoul Kopelman
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Abstract
A universal, wireless, nano-optical voltmeter comprises an organic core having at least one voltage-sensitive dye and at least one polymeric shell substantially surrounding the organic core. The nano-optical voltmeter can detect electric fields in cells. The nano-optical voltmeter allows three-dimensional E field profiling throughout the entire volume of living cells. The nano-optical voltmeter may be calibrated externally and then applied for E field determinations inside any live cell or cellular compartment, with no further calibration steps.
Claims10
A nano-optical voltmeter particle comprising:
- an organic core having at least one voltage-sensitive dye;
- at least one polymeric shell substantially surrounding said organic core;
- and
- a positively-charged coating material.
A nano-optical voltmeter particle comprising:
- an organic core having at least one voltage-sensitive dye;
- at least one polymeric shell substantially surrounding said organic core, wherein the polymeric shell is formed from polymerized silane headgroups of a mixed micelle comprising a long-chain organosilane and a surfactant;
- and
- a second silane layer comprising an amine.
Dependencies are inferred from the claim text.