Process for producing biarylphosphine compound
AssigneeNippon Chemical Industrial Co., Ltd.
InventorDaisuke Mayama
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Abstract
A process for producing a biarylphosphine compound is disclosed. The process has a step of subjecting a biarylsulfonate compound to coupling reaction with a hydrogen-phosphine compound in the presence of a catalyst and an organic strong base to obtain a biarylphosphine compound. As the catalyst, preferably used is a nickel compound or a palladium compound. As the organic strong base, preferably used is 1,8-diazabicyclo[5.4.0]undecene-7 (DBU).
Claims5
A process for producing a biarylphosphine compound comprising a step of subjecting a biarylsulfonate compound represented by general formula (1) to coupling reaction with a hydrogen-phosphine compound represented by general formula (2) in the presence of a catalyst and an organic strong base to obtain a biarylphosphine compound represented by general formula (3),
- wherein Biaryl represents a biaryl group, a substituted biaryl group, a biaryl heterocyclic group or a substituted biaryl heterocyclic group;
- E represents a sulfonate which is a leaving group, and n is an integer of 1 or more;
- H—PR1R2 (2)
- wherein R1 and R2 represent a hydrogen atom, an alkyl group, a substituted alkyl group, a cycloalkyl group, a substituted cycloalkyl group, an aralkyl group, a substituted aralkyl group, an aliphatic heterocyclic group or a substituted aliphatic heterocyclic group, and R1 and R2 may be the same or different from each other or may be linked to each other to form a bond;
- wherein Biaryl, R1, R2 and E are the same as above;
- m is 1 or more, l is 0 or more, m and 1 each are an integer satisfying m+l=n, and n is the same as above;
- and wherein the organic strong base has the following structure:
Dependencies are inferred from the claim text.