Benzene compound having 2 or more substituents

A compound represented by the general formula (I) or a pharmacologically acceptable salt or ester thereof:

• [wherein R1 represents a group having the formula —COR9 [wherein R9 represents a C1-C10 alkyl group, a C1-C10 alkoxy group, a halogeno C1-C10 alkoxy group (wherein said halogeno C1-C10 alkoxy group represents a C1-C10 alkoxy group substituted with 1 to 7 halogeno groups), a phenyl-(C1-C10 alkoxy) group, a C1-C10 alkylamino group or a di(C1-C10 alkyl)amino group (wherein said alkyl groups may be the same or different and two of said alkyl groups may, together with the nitrogen atom of said amino group, form a 5- to 7-membered saturated heterocyclyl group containing 1 to 3 atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom)];
• R2 represents a hydrogen atom, a halogeno C1-C4 alkyl group (wherein said halogeno C1-C4 alkyl group represents a C1-C4 alkyl group substituted with 1 to 5 halogeno groups), a hydroxyl group, a C1-C4 alkoxy group, an amino group, a C1-C4 alkylamino group, a di(C1-C4 alkyl)amino group (wherein said alkyl groups may be the same or different) or a halogeno group;
• R3 represents a hydrogen atom, a C1-C6 alkyl group, a halogeno C1-C6 alkyl group (wherein said halogeno C1-C6 alkyl group represents a C1-C6 alkyl group substituted with 1 to 7 halogeno groups), a (C1-C4 alkoxy)-(C1-C4 alkyl) group, a (C1-C4 alkylthio)-(C1-C4 alkyl) group, a (C1-C4 alkylsulfinyl)-(C1-C4 alkyl) group, a (C1-C4 alkylsulfonyl)-(C1-C4 alkyl) group, a (C1-C4 alkylamino)-(C1-C4 alkyl) group, a [di(C1-C4 alkyl)amino]-(C1-C4 alkyl) group (wherein said alkyl groups may be the same or different), a C3-C6 cycloalkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, a hydroxyl group, a C1-C6 alkoxy group, a halogeno C1-C6 alkoxy group (wherein said halogeno C1-C6 alkoxy group represents a C1-C6 alkoxy group substituted with 1 to 7 halogeno groups), a C1-C6 alkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, an amino group, a C1-C6 alkylamino group, a di(C1-C6 alkyl)amino group (wherein said alkyl groups may be the same or different and two of said alkyl groups may, together with the nitrogen atom of said amino group, form a 5- to 7-membered saturated heterocyclyl group containing 1 to 3 atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom), a (C1-C6 alkoxy)carbonyl group, a cyano group, a nitro group or a halogeno group;
• R4 and R5 may be the same or different and each represents a hydrogen atom, a C1-C4 alkyl group, a halogeno C1-C4 alkyl group (wherein said halogeno C1-C4 alkyl group represents a C1-C4 alkyl group substituted with 1 to 5 halogeno groups), a C3-C6 cycloalkyl group, a hydroxyl group, a C1-C4 alkoxy group, a halogeno C1-C4 alkoxy group (wherein said halogeno C1-C4 alkoxy group represents a C1-C4 alkoxy group substituted with 1 to 5 halogeno groups) or a halogeno group;
• R6 and R7 may be the same or different and each represents a hydrogen atom or a C1-C3 alkyl group;
• R8 represents a group having the formula —X2R10 [wherein R10 represents a group having the formula —COR11 [wherein R11 represents a C1-C6 alkyl group, a hydroxyl group, a C1-C6 alkoxy group, a (C3-C8 cycloalkyl)-(C1-C6 alkyl)oxy group, a C3-C8 cycloalkyloxy group, an amino group, a C1-C6 alkylamino group, a [(C3-C8 cycloalkyl)-(C1-C6 alkyl)]amino group, a C3-C8 cycloalkylamino group, a di(C1-C6 alkyl)amino group (wherein said alkyl groups may be the same or different and two of said alkyl groups may, together with the nitrogen atom of said amino group, form a 5- to 7-membered saturated heterocyclyl group containing 1 to 3 atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom), a di[(C3-C8 cycloalkyl)-(C1-C6 alkyl)]amino group, a di(C3-C8 cycloalkyl)amino group, a N—[(C3-C8 cycloalkyl)-(C1-C6 alkyl)]-N—(C1-C6 alkyl)amino group, a N—(C3-C8 cycloalkyl)-N—(C1-C6 alkyl)amino group, a N—[(C3-C8 cycloalkyl)-(C1-C6 alkyl)]-N—(C3-C8 cycloalkyl)amino group, a hydroxylamino group or a hydroxyl(C1-C6 alkyl)amino group],
• a group having the formula —SO2R12 [wherein R12 represents a C1-C6 alkyl group, a (C3-C8 cycloalkyl)-(C1-C6 alkyl) group, a C3-C8 cycloalkyl group, an amino group, a C1-C6 alkylamino group, a [(C3-C8 cycloalkyl)-(C1-C6 alkyl)]amino group, a C3-C8 cycloalkylamino group, a di(C1-C6 alkyl)amino group (wherein said alkyl groups may be the same or different and two of said alkyl groups may, together with the nitrogen atom of said amino group, form a 5- to 7-membered saturated heterocyclyl group containing 1 to 3 atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom), a di[(C3-C8 cycloalkyl)-(C1-C6 alkyl)]amino group, a di(C3-C8 cycloalkyl)amino group, a N—[(C3-C8 cycloalkyl)-(C1-C6 alkyl)]-N—(C1-C6 alkyl)amino group, a N—(C3-C8 cycloalkyl)-N—(C1-C6 alkyl)amino group or a N—[(C3-C8 cycloalkyl)-(C1-C6 alkyl)]-N—(C3-C8 cycloalkyl)amino group],
• a group having the formula —N(R13)COR14 [wherein R13 represents a hydrogen atom, a C1-C6 alkyl group, a (C3-C8 cycloalkyl)-(C1-C6 alkyl) group or a C3-C8 cycloalkyl group, and R14 represents a hydrogen atom, a C1-C6 alkyl group, a (C3-C8 cycloalkyl)-(C1-C6 alkyl) group or a C3-C8 cycloalkyl group],
• a group having the formula —N(R13)SO2R15 [wherein R13 is the same as previously defined, and R15 represents a C1-C6 alkyl group, a (C3-C8 cycloalkyl)-(C1-C6 alkyl) group or a C3-C8 cycloalkyl group], or a tetrazol-5-yl group, and
• X2 represents a single bond, a C1-C4 alkylene group or a substituted C1-C4 alkylene group (wherein said substituents may be the same or different and are one or two groups selected from Substituent group γ, or two of said substituents may together form a methylene group, an ethylene group or a trimethylene group)];
• X1 represents a group having the formula —NH— or —NR16— (wherein R16 represents a C1-C4 alkyl group), —O—, —S—, —SO— or —SO2—;
• Y1 represents a phenyl group, a substituted phenyl group (wherein said substituents may be the same or different and are 1 to 3 groups selected from Substituent group α);
• Y2 represents a 6- to 10-membered aryl group, a substituted 6- to 10-membered aryl group (wherein said substituents may be the same or different and are 1 to 3 groups selected from Substituent group β), a 9- or 10-membered unsaturated cyclic hydrocarbon group (provided that Y1 is bonded to a benzene ring part in said unsaturated cyclic hydrocarbon group), a substituted 9- or 10-membered unsaturated cyclic hydrocarbon group (provided that Y1 is bonded to a benzene ring part in said unsaturated cyclic hydrocarbon group, and said substituents may be the same or different and are 1 to 3 groups selected from Substituent group β);
• Substituent group α represents the group consisting of a C1-C4 alkyl group, a halogeno C1-C4 alkyl group (wherein said halogeno C1-C4 alkyl group represents a C1-C4 alkyl group substituted with 1 to 5 halogeno groups), a hydroxyl group, a C1-C4 alkoxy group and a halogeno group;
• Substituent group β represents the group consisting of a C1-C6 alkyl group, a hydroxy(C1-C6 alkyl) group, a carboxy(C1-C6 alkyl) group, a (C1-C6 alkoxy)carbonyl-(C1-C6 alkyl) group, a halogeno C1-C6 alkyl group (wherein said halogeno C1-C6 alkyl group represents a C1-C6 alkyl group substituted with 1 to 7 halogeno atoms), a (C3-C8 cycloalkyl)-(C1-C6 alkyl) group, a C2-C7 alkenyl group, a C2-C7 alkynyl group, a C3-C8 cycloalkyl group, a hydroxyl group, a C1-C6 alkoxy group, a halogeno C1-C6 alkoxy group (wherein said halogeno C1-C6 alkoxy group represents a C1-C6 alkoxy group substituted with 1 to 7 halogeno groups), a C1-C6 alkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, an amino group, a C1-C6 alkylamino group, a C3-C8 cycloalkylamino group, a di(C1-C6 alkyl)amino group (wherein said alkyl groups may be the same or different and two of said alkyl groups may, together with the nitrogen atom of said amino group, form a 5- to 7-membered saturated heterocyclyl group containing 1 to 3 atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom), a di(C3-C8 cycloalkyl)amino group, a N—(C3-C8 cycloalkyl)-N—(C1-C6 alkyl)amino group, a formylamino group, a (C1-C6 alkyl)carbonylamino group, a (C3-C8 cycloalkyl)carbonylamino group, a N—[(C1-C6 alkyl)carbonyl]-N—(C1-C6 alkyl)amino group, a N—[(C3-C8 cycloalkyl)carbonyl]-N—(C1-C6 alkyl)amino group, a C1-C6 alkylsulfonylamino group, a N—(C1-C6 alkylsulfonyl)-N—(C1-C6 alkyl)amino group, a N—(C1-C6 alkylsulfonyl)-N—(C3-C8 cycloalkyl)amino group, a formyl group, a (C1-C6 alkyl)carbonyl group, a carboxyl group, a (C1-C6 alkoxy)carbonyl group, a carbamoyl group, a (C1-C6 alkylamino)carbonyl group, a (C3-C8 cycloalkylamino)carbonyl group, a di(C1-C6 alkyl)aminocarbonyl group (wherein said alkyl groups may be the same or different and two of said alkyl groups may, together with the nitrogen atom of said amino group, form a 5- to 7-membered saturated heterocyclyl group containing 1 to 3 atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom), a N—(C3-C8 cycloalkyl)-N—(C1-C6 alkyl)aminocarbonyl group, a cyano group, a nitro group and a halogeno group;
• and,
• Substituent group γ represents the group consisting of a C1-C6 alkyl group, a hydroxy(C1-C6 alkyl) group, a (C1-C6 alkoxy)-(C1-C6 alkyl) group, a mercapto(C1-C6 alkyl) group, a (C1-C6 alkylthio)-(C1-C6 alkyl) group, a (C1-C6 alkylsulfinyl)-(C1-C6 alkyl) group, a (C1-C6 alkylsulfonyl)-(C1-C6 alkyl) group, an amino(C1-C6 alkyl) group, a (C1-C6 alkylamino)-(C1-C6 alkyl) group, a (C3-C8 cycloalkylamino)-(C1-C6 alkyl) group, a di(C1-C6 alkyl)amino-(C1-C6 alkyl) group (wherein said alkyl groups may be the same or different and two of said alkyl groups of the di(C1-C6 alkyl)amino moiety may, together with the nitrogen atom of said amino group, form a 5- to 7-membered saturated heterocyclyl group containing 1 to 3 atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom), a di(C3-C8 cycloalkyl)amino-(C1-C6 alkyl) group, a [N—(C3-C8 cycloalkyl)-N—(C1-C6 alkyl)amino]-(C1-C6 alkyl) group, a hydroxyl group, a C1-C6 alkoxy group, a C3-C8 cycloalkyloxy group, a mercapto group, a C1-C6 alkylthio group, a C3-C8 cycloalkylthio group, a C1-C6 alkylsulfinyl group, a C3-C8 cycloalkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C3-C8 cycloalkylsulfonyl group, an amino group, a C1-C6 alkylamino group, a C3-C8 cycloalkylamino group, a di(C1-C6 alkyl)amino group (wherein said alkyl groups may be the same or different and two of said alkyl groups may, together with the nitrogen atom of said amino group, form a 5- to 7-membered saturated heterocyclyl group containing 1 to 3 atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom), a di(C3-C8 cycloalkyl)amino group, a N—(C3-C8 cycloalkyl)-N—(C1-C6 alkyl)amino group and a halogeno group].